Mitochondrial Ca 2+ -Activated K + Channels in Cardiac Myocytes
نویسندگان
چکیده
منابع مشابه
Mitochondrial Ca -Activated K Channels in Cardiac Myocytes A Mechanism of the Cardioprotective Effect and Modulation by Protein Kinase A
Background—The large-conductance Ca -activated K (BKCa) channel in the cardiac inner mitochondrial membrane (mitoKCa channel) has been shown to protect the heart against ischemic injury. However, questions about the cardioprotective mechanism and the kinase-mediated regulation of mitoKCa channels remain to be answered. Methods and Results—Flavoprotein fluorescence in guinea pig ventricular myoc...
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Using the patch-clamp technique, we have identified two types of Ca(2+)-activated K+ (K(Ca)) channels in the human leukemic T cell line. Jurkat. Substances that elevate the intracellular Ca2+ concentration ([Ca2+]i), such as ionomycin or the mitogenic lectin phytohemagglutinin (PHA), as well as whole-cell dialysis with pipette solutions containing elevated [Ca2+]i, activate a voltage-independen...
متن کاملMitochondrial Ca2+-activated K+ channels more efficiently reduce mitochondrial Ca2+ overload in rat ventricular myocytes.
We investigated the role of the mitochondrial ATP-sensitive K(+) (K(ATP)) channel, the mitochondrial big-conductance Ca(2+)-activated K(+) (BK(Ca)) channel, and the mitochondrial permeability transition pore (MPTP) in the ouabain-induced increase of mitochondrial Ca(2+) in native rat ventricular myocytes by loading cells with rhod 2-AM. To overload mitochondrial Ca(2+), we pretreated cells with...
متن کاملMitochondrial Ca2+-activated K+ channels in cardiac myocytes: a mechanism of the cardioprotective effect and modulation by protein kinase A.
BACKGROUND The large-conductance Ca2+-activated K+ (BK(Ca)) channel in the cardiac inner mitochondrial membrane (mitoK(Ca) channel) has been shown to protect the heart against ischemic injury. However, questions about the cardioprotective mechanism and the kinase-mediated regulation of mitoK(Ca) channels remain to be answered. METHODS AND RESULTS Flavoprotein fluorescence in guinea pig ventri...
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Large-conductance Ca-dependent K channels (KCa), which are abundant on the sarcolemma of vascular myocytes, provide negative feedback via membrane hyperpolarization that limits Ca entry through L-type Ca channels (ICaL). We hypothesize that local accumulation of subsarcolemmal Ca 21 during ICaL openings amplifies this feedback. Our goal was to demonstrate that Ca entry through voltage-gated ICa...
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ژورنال
عنوان ژورنال: Circulation
سال: 2005
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000151099.15706.b1